Recente publicatie 2018:
Samenvatting:
Als de rook is opgetrokken: Psychose, roken en cognitie.
Waarom dit onderzoek?
Patiënten met een psychose roken veel vaker sigaretten dan mensen uit de algemene bevolking. Daarnaast ervaren veel patiënten problemen met de uitvoering van cognitieve taken zoals ordelijk denken, plannen en het nemen van besluiten. Of roken op lange-termijn samenhangt met cognitieve voor- of nadelen bij deze groep patiënten is niet eerder onderzocht.
Onderzoeksvragen
i) Hangt roken samen met cognitief functioneren in patiënten met een psychose, broers en zussen van patiënten en gezonde controles?
ii) Gaat stoppen of starten met roken gepaard met verandering in cognitief functioneren?
Hoe werd dit onderzocht?
In het GROUP project zijn 1094 patiënten met een psychose, 1047 broers en zussen van patiënten met een psychose en 579 gezonde controles 6 jaar gevolgd. Bij de start van de studie, 3 en 6 jaar later werd gevraagd naar roken en het aantal sigaretten per dag. Daarnaast werden verschillende taken getest die horen bij het cognitief functioneren.
Belangrijkste resultaten
In totaal rookten 67% van de patiënten tegenover 38% van de broers en zussen van deze patienten en 25% van de controles. Rokers uit alle groepen presteerden cognitief slechter dan niet-rokers. Bovendien ging stoppen met roken door patiënten gepaard met een verbetering in de snelheid van informatieverwerking.
Consequenties voor de praktijk
Behandeling van een rookverslaving onder patiënten met een psychose behoeft extra aandacht. Patiënten roken niet alleen veel vaker, het hangt ook samen met een slechter cognitief functioneren. Stoppen met roken leidt mogelijk tot een verbetering van de snelheid waarmee patiënten met een psychose informatie kunnen verwerken.
Jentien Vermeulen, M.D., Frederike Schirmbeck, Ph.D., Matthijs Blankers, Ph.D.,
Mirjam van Tricht, Ph.D., Richard Bruggeman, M.D., Ph.D., Wim van den Brink, M.D., Ph.D.,
Lieuwe de Haan, M.D., Ph.D.,
j.m.vermeulen@amc.uva.nl
Association Between Smoking Behavior and Cognitive Functioning in Patients With Psychosis, Siblings, and Healthy Control Subjects: Results From a Prospective 6-Year Follow-Up Study
The American Journal of Psychiatry, 2018, ahead of print.
https://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.18010069
Roken, cognitief functioneren, psychose
- Developmental course of subclinical positive and negative psychotic symptoms and their associations with genetic risk status and impairment
Janssens M, Boyette LL, Heering HD, Bartels-Velthuis AA, Lataster T, - mei 4, 2016 - Cognitive Performance and Long-Term Social Functioning in Psychotic Disorder: A Three-Year Follow-Up Study
Simons CJ, Bartels-Velthuis AA, Pijnenborg GH, - april 15, 2016 - Disturbed Experience of Self: Psychometric Analysis of the Self-Experience Lifetime Frequency Scale (SELF)
Heering HD, Goedhart S, Bruggeman R, Cahn W, de Haan L, Kahn RS, Meijer CJ, Myin-Germeys I, van Os J, Wiersma D - maart 19, 2016 - The prevalence of visual hallucinations in non-affective psychosis, and the role of perception and attention
van Ommen MM, van Beilen M, Cornelissen FW, Smid HG, Knegtering H, Aleman A, van Laar T, - maart 17, 2016 - Longitudinal association between cognitive performance and obsessive-compulsive symptoms in patients with psychosis and unaffected siblings
Schirmbeck F, Swets M, Meijer CJ, Zink M, de Haan L, - februari 10, 2016 - Social functioning in patients with a psychotic disorder and first rank symptoms
Heering HD, van Haren NE, - januari 22, 2016 - Metabolic syndrome in schizophrenia patients associated with poor premorbid school performance in early adolescence
de Nijs J, Pet MA, - november 12, 2015
- [The association between cognitive deficits and different outcomes of schizophrenia]
de Nijs J, Zoun K, Investigators G - juni 28, 2016 - The association between antibodies to neurotropic pathogens and schizophrenia: a case-control study
de Witte LD, van Mierlo HC, Litjens M, Klein HC, Bahn S, Osterhaus AD, - november 4, 2015 - Semi-metric analysis of the functional brain network: Relationship with familial risk for psychotic disorder
Peeters S, Simas T, Suckling J, Gronenschild E, Patel A, Habets P, van Os J, Marcelis M, - oktober 9, 2015 - No evidence for the presence of neuronal surface autoantibodies in plasma of patients with schizophrenia
van Mierlo HC, van Coevorden-Hameete MH, Munting LP, de Graaff E, de Witte L, - oktober 8, 2015 - Further Evidence That Cannabis Moderates Familial Correlation of Psychosis-Related Experiences
van Winkel R, - september 18, 2015 - Bone Mineral Density as a Marker of Cumulative Estrogen Exposure in Psychotic Disorder: A 3 Year Follow-Up Study
van der Leeuw C, Peeters S, Domen P, van Kroonenburgh M, van Os J, Marcelis M, - augustus 26, 2015 - Psychotic disorder and educational achievement: a family-based analysis
Frissen A, Lieverse R, Marcelis M, Drukker M, Delespaul P, - juni 23, 2015 - Evidence for a Shared Etiological Mechanism of Psychotic Symptoms and Obsessive-Compulsive Symptoms in Patients with Psychotic Disorders and Their Siblings
Swets M, Van Dael F, Roza S, Schoevers R, Myin-Germeys I, de Haan L, - juni 10, 2015 - Course of cannabis use and clinical outcome in patients with non-affective psychosis: a 3-year follow-up study
van der Meer FJ, Velthorst E - mei 6, 2015 - Childhood trauma and childhood urbanicity in relation to psychotic disorder
Frissen A, Lieverse R, Drukker M, van Winkel R, Delespaul P, - april 21, 2015 - Associations between stereotype awareness, childhood trauma and psychopathology: a study in people with psychosis, their siblings and controls
van Zelst C, van Nierop M, van Dam DS, Bartels-Velthuis AA, Delespaul P, - februari 23, 2015 - Course of cannabis use and clinical outcome in patients with non-affective psychosis: a 3-year follow-up study
van der Meer FJ, Velthorst E, - februari 5, 2015 - Emotion processing in schizophrenia is state and trait dependent
Maat A, van Montfort SJ, de Nijs J, Derks EM, Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I, - december 24, 2014 - Remission criteria and functional outcome in patients with schizophrenia, a longitudinal study
Heering HD, Janssens M, Boyette LL, van Haren NE, - november 18, 2014 - Childhood trauma is associated with a specific admixture of affective, anxiety, and psychosis symptoms cutting across traditional diagnostic boundaries
van Nierop M, Viechtbauer W, Gunther N, van Zelst C, de Graaf R, Ten Have M, van Dorsselaer S, Bak M, , van Winkel R - oktober 2, 2014
- [The association between cognitive deficits and different outcomes of schizophrenia]
de Nijs J, Zoun K, Investigators G - juni 28, 2016 - Evidence That Environmental and Genetic Risks for Psychotic Disorder May Operate by Impacting on Connections Between Core Symptoms of Perceptual Alteration and Delusional Ideation
Smeets F, Lataster T, Viechtbauer W, Delespaul P, - september 12, 2014 - Psychometric properties of the self-report version of the Quick Inventory of Depressive Symptoms (QIDS-SR16) questionnaire in patients with schizophrenia
Lako IM, Wigman JT, Klaassen RM, Slooff CJ, Taxis K, Bartels-Velthuis AA - september 3, 2014 - Factors contributing to the duration of untreated psychosis
Apeldoorn SY, Sterk B, van den Heuvel ER, Schoevers RA, Islam MA, , - juli 18, 2014 - Childhood abuse and neglect in relation to the presence and persistence of psychotic and depressive symptomatology
van Dam DS, van Nierop M, Viechtbauer W, Velthorst E, van Winkel R, , Bruggeman R, Cahn W, de Haan L, Kahn RS, Meijer CJ, Myin-Germeys I, van Os J, Wiersma D - juli 17, 2014 - Premorbid adjustment profiles in psychosis and the role of familial factors
Quee PJ, Meijer JH, Islam MA, Aleman A, Alizadeh BZ, Meijer CJ, van den Heuvel ER, - juli 7, 2014 - Stereotype awareness, self-esteem and psychopathology in people with psychosis
van Zelst C, van Nierop M, Oorschot M, Myin-Germeys I, van Os J, Delespaul P, - februari 11, 2014
- Cognitive functioning associated with stimulant use in patients with non-affective psychosis, their unaffected siblings and healthy controls
van der Meer FJ, Meijer JH, Meijer CJ, van den Brink W, Velthorst E - november 22, 2013 - Evidence that transition from health to psychotic disorder can be traced to semi-ubiquitous environmental effects operating against background genetic risk
van Nierop M, Janssens M, , Bruggeman R, Cahn W, de Haan L, Kahn RS, Meijer CJ, Myin-Germeys I, van Os J, Wiersma D - november 6, 2013 - The association between intelligence scores and family history of psychiatric disorder in schizophrenia patients, their siblings and healthy controls
Verweij KH, Derks EM, - oktober 9, 2013 - The effect of childhood maltreatment and cannabis use on adult psychotic symptoms is modified by the COMT Val¹⁵⁸Met polymorphism
Vinkers CH, Van Gastel WA, Schubart CD, Van Eijk KR, Luykx JJ, Van Winkel R, Joëls M, Ophoff RA, Boks MP, , Bruggeman R, Cahn W, de Haan L, Kahn RS, Meijer CJ, Myin-Germeys I, van Os J, Wiersma D - augustus 15, 2013 - A two-factor structure of first rank symptoms in patients with a psychotic disorder
Heering HD, van Haren NE, Derks EM, - juni 2, 2013 - Substance use in a large sample of patients with schizophrenia or related disorders and co-morbid obsessive-compulsive symptoms
Dekker N, Swets M, - mei 30, 2013 - Cognitive subtypes in non-affected siblings of schizophrenia patients: characteristics and profile congruency with affected family members
Quee PJ, Alizadeh BZ, Aleman A, van den Heuvel ER, - mei 9, 2013 - Insight change in psychosis: relationship with neurocognition, social cognition, clinical symptoms and phase of illness
Quee PJ, van der Meer L, Krabbendam L, de Haan L, Cahn W, Wiersma D, van Beveren N, Pijnenborg GH, Mulder CL, Bruggeman R, Aleman A - april 18, 2013 - Effect of illness expression and liability on familial associations of clinical and subclinical psychosis phenotypes
Lataster T, Verweij K, Viechtbauer W, - maart 7, 2013 - Is a schizo-obsessive subtype associated with cognitive impairment? Results from a large cross-sectional study in patients with psychosis and their unaffected relatives
Meijer JH, Swets M, Keeman S, Nieman DH, Meijer CJ, - januari 1, 2013
- Replication and refinement of the role of rs548181 in schizophrenia: results from a family based study
Derks EM, Ophoff RA, - november 28, 2012 - Obsessive-compulsive symptoms in patients with schizophrenia: a naturalistic cross-sectional study comparing treatment with clozapine, olanzapine, risperidone, and no antipsychotics in 543 patients
Scheltema Beduin AA, Swets M, Machielsen M, Korver N, - november 1, 2012 - Using multidimensional modeling to combine self-report symptoms with clinical judgment of schizotypy
van den Berg SM, Paap MC, Derks EM, - september 27, 2012 - Craving for cannabis in patients with psychotic disorder, their non-affected siblings and healthy controls: psychometric analysis of the obsessive compulsive drug use scale
Dekker N, Koeter M, Van Den Brink W, - september 10, 2012 - Depressive symptoms are associated with (sub)clinical psychotic symptoms in patients with non-affective psychotic disorder, siblings and healthy controls
Klaassen RM, Heins M, Luteijn LB, van der Gaag M, van Beveren NJ, - juli 18, 2012 - The identification of family subtype based on the assessment of subclinical levels of psychosis in relatives
Derks EM, Boks MP, Vermunt JK, - juli 3, 2012 - Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis
Derks EM, Vorstman JA, Ripke S, Kahn RS, , Ophoff RA - juni 22, 2012 - Segment-wise genome-wide association analysis identifies a candidate region associated with schizophrenia in three independent samples
Gladwin TE, Derks EM, , Rietschel M, Mattheisen M, Breuer R, Schulze TG, Nöthen MM, Levinson D, Shi J, Gejman PV, Cichon S, Ophoff RA - juni 18, 2012 - Cognitive functioning and age at onset in non-affective psychotic disorder
van der Werf M, Köhler S, Verkaaik M, Verhey F, van Os J, - mei 14, 2012 - Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorder
Vassos E, Steinberg S, Cichon S, Breen G, Sigurdsson E, Andreassen OA, Djurovic S, Morken G, Grigoroiu-Serbanescu M, Diaconu CC, Czerski PM, Hauser J, Babadjanova G, Abramova LI, Mühleisen TW, Nöthen MM, Rietschel M, McGuffin P, St Clair D, Gustafsson O, Melle I, Pietiläinen OP, Ruggeri M, Tosato S, Werge T, Ophoff RA, , Rujescu D, Børglum AD, Mors O, Mortensen PB, Demontis D, Hollegaard MV, van Winkel R, Kenis G, De Hert M, Réthelyi JM, Bitter I, Rubino IA, Golimbet V, Kiemeney LA, van den Berg LH, Franke B, Jönsson EG, Farmer A, Stefansson H, Stefansson K, Collier DA - mei 5, 2012 - Intermediate phenotype analysis of patients, unaffected siblings, and healthy controls identifies VMAT2 as a candidate gene for psychotic disorder and neurocognition
Simons CJ, van Winkel R, - april 24, 2012 - The association between social anhedonia, withdrawal and psychotic experiences in general and high-risk populations
Velthorst E, Meijer C, - april 6, 2012 - No evidence for familial covariation of neurocognition and negative symptoms in psychotic disorders
Lataster T, Shazad A, Henquet C, Quee P, - april 3, 2012 - Age at onset of non-affective psychosis in relation to cannabis use, other drug use and gender
Dekker N, Meijer J, Koeter M, van den Brink W, van Beveren N, Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I, - maart 27, 2012 - Genetic Risk and Outcome of Psychosis (GROUP), a multi-site longitudinal cohort study focused on gene-environment interaction: objectives, sample characteristics, recruitment and assessment methods
Korver N, Quee PJ, Boos HB, Simons CJ, de Haan L, - maart 15, 2012 - Social cognition and quality of life in schizophrenia
Maat A, Fett AK, Derks E, - maart 8, 2012 - Clinical response to antipsychotic drug treatment: association study of polymorphisms in six candidate genes
Vehof J, Burger H, Wilffert B, Al Hadithy A, Alizadeh BZ, Snieder H, - maart 3, 2012
- The validity of the DSM-IV diagnostic classification system of non-affective psychoses
Korver-Nieberg N, Quee PJ, Boos HB, Simons CJ, - oktober 25, 2011 - Cognitive alterations in patients with non-affective psychotic disorder and their unaffected siblings and parents
Meijer J, Simons CJ, Quee PJ, Verweij K, - oktober 20, 2011 - Genome-wide association study identifies five new schizophrenia loci
- september 18, 2011 - Cannabis and cognitive performance in psychosis: a cross-sectional study in patients with non-affective psychotic illness and their unaffected siblings
Meijer JH, Dekker N, Koeter MW, Quee PJ, van Beveren NJ, Meijer CJ, - september 7, 2011 - AKT1 moderation of cannabis-induced cognitive alterations in psychotic disorder
van Winkel R, van Beveren NJ, Simons C, - juli 20, 2011 - Differences in craving for cannabis between schizophrenia patients using risperidone, olanzapine or clozapine
Machielsen M, Beduin AS, Dekker N, , Kahn RS, Linszen DH, van Os J, Wiersma D, Bruggeman R, Cahn W, de Haan L, Krabbendam L, Myin-Germeys I - juli 18, 2011 - Association of two DRD2 gene polymorphisms with acute and tardive antipsychotic-induced movement disorders in young Caucasian patients
Koning JP, Vehof J, Burger H, Wilffert B, Al Hadithy A, Alizadeh B, van Harten PN, Snieder H, - juli 13, 2011 - Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe
Rietschel M, Mattheisen M, Degenhardt F, , Mühleisen TW, Kirsch P, Esslinger C, Herms S, Demontis D, Steffens M, Strohmaier J, Haenisch B, Breuer R, Czerski PM, Giegling I, Strengman E, Schmael C, Mors O, Mortensen PB, Hougaard DM, Ørntoft T, Kapelski P, Priebe L, Basmanav FF, Forstner AJ, Hoffman P, Meier S, Nikitopoulos J, Moebus S, Alexander M, Mössner R, Wichmann H-, Schreiber S, Rivandeneira F, Hofman A, Uitterlinden AG, Wienker TF, Schumacher J, Hauser J, Maier W, Cantor RM, Erk S, Schulze TG, , Craddock N, Owen MJ, O'Donovan MC, Børglum AD, Rujescu D, Walter H, Meyer-Lindenberg A, Nöthen NM, Ophoff RA, Cichon S - juli 12, 2011 - Social cognitive impairments and psychotic symptoms: what is the nature of their association?
Fett AK, Maat A, - juni 22, 2011 - Genome-wide analysis shows increased frequency of copy number variation deletions in Dutch schizophrenia patients
Buizer-Voskamp JE, Muntjewerff JW, , Strengman E, Sabatti C, Stefansson H, Vorstman JA, Ophoff RA - april 13, 2011
- Effects of season of birth and a common MTHFR gene variant on the risk of schizophrenia
Muntjewerff JW, Ophoff RA, Buizer-Voskamp JE, Strengman E, den Heijer M, - november 19, 2010 - Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up
van Winkel R, - november 1, 2010 - Evidence that familial liability for psychosis is expressed as differential sensitivity to cannabis: an analysis of patient-sibling and sibling-control pairs
- oktober 4, 2010 - Kraepelin was right: a latent class analysis of symptom dimensions in patients and controls
Derks EM, Allardyce J, Boks MP, Vermunt JK, Hijman R, Ophoff RA, - september 23, 2010 - GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia
Chen X, Lee G, Maher BS, Fanous AH, Chen J, Zhao Z, Guo A, van den Oord E, Sullivan PF, Shi J, Levinson DF, Gejman PV, Sanders A, Duan J, Owen MJ, Craddock NJ, O'Donovan MC, Blackman J, Lewis D, Kirov GK, Qin W, Schwab S, Wildenauer D, Chowdari K, Nimgaonkar V, Straub RE, Weinberger DR, O'Neill FA, Walsh D, Bronstein M, Darvasi A, Lencz T, Malhotra AK, Rujescu D, Giegling I, Werge T, Hansen T, Ingason A, Nöethen MM, Rietschel M, Cichon S, Djurovic S, Andreassen OA, Cantor RM, Ophoff R, Corvin A, Morris DW, Gill M, Pato CN, Pato MT, Macedo A, Gurling HM, McQuillin A, Pimm J, Hultman C, Lichtenstein P, Sklar P, Purcell SM, Scolnick E, St Clair D, Blackwood DH, Kendler KS, , - september 14, 2010 - Factor structure of the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) in a large sample of patients with schizophrenia or related disorders and comorbid obsessive-compulsive symptoms
Boyette L, Swets M, Meijer C, Wouters L, G R O U P Authors - augustus 30, 2010 - Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder
Williams HJ, Norton N, Dwyer S, Moskvina V, Nikolov I, Carroll L, Georgieva L, Williams NM, Morris DW, Quinn EM, Giegling I, Ikeda M, Wood J, Lencz T, Hultman C, Lichtenstein P, Thiselton D, Maher BS, , Malhotra AK, Riley B, Kendler KS, Gill M, Sullivan P, Sklar P, Purcell S, Nimgaonkar VL, Kirov G, Holmans P, Corvin A, Rujescu D, Craddock N, Owen MJ, O'Donovan MC - april 6, 2010 - A large replication study and meta-analysis in European samples provides further support for association of AHI1 markers with schizophrenia
Ingason A, Giegling I, Cichon S, Hansen T, Rasmussen HB, Nielsen J, Jürgens G, Muglia P, Hartmann AM, Strengman E, Vasilescu C, Mühleisen TW, Djurovic S, Melle I, Lerer B, Möller HJ, Francks C, Pietiläinen OP, Lonnqvist J, Suvisaari J, Tuulio-Henriksson A, Walshe M, Vassos E, Di Forti M, Murray R, Bonetto C, Tosato S, , Cantor RM, Rietschel M, Craddock N, Owen MJ, Peltonen L, Andreassen OA, Nöthen MM, St Clair D, Ophoff RA, O'Donovan MC, Collier DA, Werge T, Rujescu D - januari 12, 2010 - Expanding the range of ZNF804A variants conferring risk of psychosis
Steinberg S, Mors O, Børglum AD, Gustafsson O, Werge T, Mortensen PB, Andreassen OA, Sigurdsson E, Thorgeirsson TE, Böttcher Y, Olason P, Ophoff RA, Cichon S, Gudjonsdottir IH, Pietiläinen OP, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Athanasiu L, Suvisaari J, Lonnqvist J, Paunio T, Hartmann A, Jürgens G, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Breuer R, Möller HJ, Giegling I, Glenthøj B, Rasmussen HB, Mattheisen M, Bitter I, Réthelyi JM, Sigmundsson T, Fossdal R, Thorsteinsdottir U, Ruggeri M, Tosato S, Strengman E, , Kiemeney LA, Melle I, Djurovic S, Abramova L, Kaleda V, Walshe M, Bramon E, Vassos E, Li T, Fraser G, Walker N, Toulopoulou T, Yoon J, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Jönsson EG, Terenius L, Agartz I, Petursson H, Nöthen MM, Rietschel M, Peltonen L, Rujescu D, Collier DA, Stefansson H, St Clair D, Stefansson K - januari 5, 2010
- Copy number variations of chromosome 16p13.1 region associated with schizophrenia
Ingason A, Rujescu D, Cichon S, Sigurdsson E, Sigmundsson T, Pietiläinen OP, Buizer-Voskamp JE, Strengman E, Francks C, Muglia P, Gylfason A, Gustafsson O, Olason PI, Steinberg S, Hansen T, Jakobsen KD, Rasmussen HB, Giegling I, Möller HJ, Hartmann A, Crombie C, Fraser G, Walker N, Lonnqvist J, Suvisaari J, Tuulio-Henriksson A, Bramon E, Kiemeney LA, Franke B, Murray R, Vassos E, Toulopoulou T, Mühleisen TW, Tosato S, Ruggeri M, Djurovic S, Andreassen OA, Zhang Z, Werge T, Ophoff RA, , Rietschel M, Nöthen MM, Petursson H, Stefansson H, Peltonen L, Collier D, Stefansson K, St Clair DM - september 29, 2009 - Common variants conferring risk of schizophrenia
Stefansson H, Ophoff RA, Steinberg S, Andreassen OA, Cichon S, Rujescu D, Werge T, Pietiläinen OP, Mors O, Mortensen PB, Sigurdsson E, Gustafsson O, Nyegaard M, Tuulio-Henriksson A, Ingason A, Hansen T, Suvisaari J, Lonnqvist J, Paunio T, Børglum AD, Hartmann A, Fink-Jensen A, Nordentoft M, Hougaard D, Norgaard-Pedersen B, Böttcher Y, Olesen J, Breuer R, Möller HJ, Giegling I, Rasmussen HB, Timm S, Mattheisen M, Bitter I, Réthelyi JM, Magnusdottir BB, Sigmundsson T, Olason P, Masson G, Gulcher JR, Haraldsson M, Fossdal R, Thorgeirsson TE, Thorsteinsdottir U, Ruggeri M, Tosato S, Franke B, Strengman E, Kiemeney LA, , Melle I, Djurovic S, Abramova L, Kaleda V, Sanjuan J, de Frutos R, Bramon E, Vassos E, Fraser G, Ettinger U, Picchioni M, Walker N, Toulopoulou T, Need AC, Ge D, Yoon JL, Shianna KV, Freimer NB, Cantor RM, Murray R, Kong A, Golimbet V, Carracedo A, Arango C, Costas J, Jönsson EG, Terenius L, Agartz I, Petursson H, Nöthen MM, Rietschel M, Matthews PM, Muglia P, Peltonen L, St Clair D, Goldstein DB, Stefansson K, Collier DA - juli 1, 2009
- Disruption of the neurexin 1 gene is associated with schizophrenia
Rujescu D, Ingason A, Cichon S, Pietiläinen OP, Barnes MR, Toulopoulou T, Picchioni M, Vassos E, Ettinger U, Bramon E, Murray R, Ruggeri M, Tosato S, Bonetto C, Steinberg S, Sigurdsson E, Sigmundsson T, Petursson H, Gylfason A, Olason PI, Hardarsson G, Jonsdottir GA, Gustafsson O, Fossdal R, Giegling I, Möller HJ, Hartmann AM, Hoffmann P, Crombie C, Fraser G, Walker N, Lonnqvist J, Suvisaari J, Tuulio-Henriksson A, Djurovic S, Melle I, Andreassen OA, Hansen T, Werge T, Kiemeney LA, Franke B, Veltman J, Buizer-Voskamp JE, , Sabatti C, Ophoff RA, Rietschel M, Nöthen MM, Stefansson K, Peltonen L, St Clair D, Stefansson H, Collier DA - oktober 22, 2008 - Recurrent CNVs disrupt three candidate genes in schizophrenia patients
Vrijenhoek T, Buizer-Voskamp JE, van der Stelt I, Strengman E, , Sabatti C, Geurts van Kessel A, Brunner HG, Ophoff RA, Veltman JA - oktober 1, 2008 - Large recurrent microdeletions associated with schizophrenia
Stefansson H, Rujescu D, Cichon S, Pietiläinen OP, Ingason A, Steinberg S, Fossdal R, Sigurdsson E, Sigmundsson T, Buizer-Voskamp JE, Hansen T, Jakobsen KD, Muglia P, Francks C, Matthews PM, Gylfason A, Halldorsson BV, Gudbjartsson D, Thorgeirsson TE, Sigurdsson A, Jonasdottir A, Jonasdottir A, Bjornsson A, Mattiasdottir S, Blondal T, Haraldsson M, Magnusdottir BB, Giegling I, Möller HJ, Hartmann A, Shianna KV, Ge D, Need AC, Crombie C, Fraser G, Walker N, Lonnqvist J, Suvisaari J, Tuulio-Henriksson A, Paunio T, Toulopoulou T, Bramon E, Di Forti M, Murray R, Ruggeri M, Vassos E, Tosato S, Walshe M, Li T, Vasilescu C, Mühleisen TW, Wang AG, Ullum H, Djurovic S, Melle I, Olesen J, Kiemeney LA, Franke B, , Sabatti C, Freimer NB, Gulcher JR, Thorsteinsdottir U, Kong A, Andreassen OA, Ophoff RA, Georgi A, Rietschel M, Werge T, Petursson H, Goldstein DB, Nöthen MM, Peltonen L, Collier DA, St Clair D, Stefansson K - september 1, 2008